{"id":3958,"date":"2024-11-05T06:42:30","date_gmt":"2024-11-05T06:42:30","guid":{"rendered":"https:\/\/www.liferxpharmacy.com\/blog\/?p=3958"},"modified":"2024-11-05T07:01:47","modified_gmt":"2024-11-05T07:01:47","slug":"empagliflozin-vs-metformin","status":"publish","type":"post","link":"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/","title":{"rendered":"Difference Between Empagliflozin &#038; Metformin"},"content":{"rendered":"\n<p>When it comes to managing type 2 diabetes, understanding the various treatment options available is crucial. <a href=\"https:\/\/www.liferxpharmacy.com\/products\/synjardy.html\"><strong>Synjardy Empagliflozin<\/strong> &amp; <strong>Metformin<\/strong><\/a> are two commonly prescribed medications, each playing a unique role in glucose control. Metformin, often considered the first-line treatment, primarily works by reducing glucose production in the liver and improving insulin sensitivity.<\/p>\n\n\n\n<p>On the other hand, Synjardy combines metformin with empagliflozin, an SGLT2 inhibitor, which not only helps lower blood sugar but also promotes weight loss and provides additional kidney protection. While both medications aim to achieve similar outcomes\u2014better blood sugar control\u2014they differ in their mechanisms, dosing, potential side effects, and overall benefits.<\/p>\n\n\n\n<p>Understanding such differences may aid in making informed decisions among patients together with their doctors. This blog will explore the key distinctions between Synjardy Empagliflozin and metformin, offering insights into their unique features, benefits, and considerations for effective diabetes management.<\/p>\n\n\n\n<h2 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"Complete_overview_of_Synjardy_Empagliflozin_Metformin\"><\/span>Complete overview of Synjardy Empagliflozin &amp; Metformin<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_47_1 counter-hierarchy ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">Important Checkpoints<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"ez-toc-toggle-icon-1\"><label for=\"item-69f0db58b7f11\" aria-label=\"Table of Content\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-69f0db58b7f11\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-visibility-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Complete_overview_of_Synjardy_Empagliflozin_Metformin\" title=\"Complete overview of Synjardy Empagliflozin &amp; Metformin\">Complete overview of Synjardy Empagliflozin &amp; Metformin<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#How_Synjardy_Works\" title=\"How Synjardy Works\">How Synjardy Works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Benefits_of_Synjardy\" title=\"Benefits of Synjardy\">Benefits of Synjardy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Dosage_Forms\" title=\"Dosage Forms\">Dosage Forms<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Synjardy_Empagliflozin_Metformin_for_weight_loss\" title=\"Synjardy Empagliflozin &amp; Metformin for weight loss\">Synjardy Empagliflozin &amp; Metformin for weight loss<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#1_How_Synjardy_Affects_Weight_Loss\" title=\"1. How Synjardy Affects Weight Loss\">1. How Synjardy Affects Weight Loss<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#2_Weight_Loss_Benefits_of_Synjardy\" title=\"2. Weight Loss Benefits of Synjardy\">2. Weight Loss Benefits of Synjardy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#3_How_Effective_is_Synjardy_for_Weight_Loss\" title=\"3. How Effective is Synjardy for Weight Loss?\">3. How Effective is Synjardy for Weight Loss?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Cost_of_Synjardy_Empagliflozin_Metformin\" title=\"Cost of Synjardy Empagliflozin &amp; Metformin\">Cost of Synjardy Empagliflozin &amp; Metformin<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#What_is_the_suitable_time_to_take_Synjardy\" title=\"What is the suitable time to take Synjardy?\">What is the suitable time to take Synjardy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Does_Synjardy_affect_the_liver\" title=\"Does Synjardy affect the liver?\">Does Synjardy affect the liver?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Is_Metformin_good_for_diabetes\" title=\"Is Metformin good for diabetes?\">Is Metformin good for diabetes?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#Is_Synjardy_bad_for_the_kidney\" title=\"Is Synjardy bad for the kidney?\">Is Synjardy bad for the kidney?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/#References\" title=\"References\">References<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<figure class=\"is-layout-flex wp-block-gallery-1 wp-block-gallery has-nested-images columns-default is-cropped\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"647\" data-id=\"3959\" src=\"https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Overview-of-SynjardyMetformin-1024x647.png\" alt=\"Complete overview of Synjardy Empagliflozin &amp; Metformin\" class=\"wp-image-3959\" srcset=\"https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Overview-of-SynjardyMetformin-1024x647.png 1024w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Overview-of-SynjardyMetformin-300x190.png 300w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Overview-of-SynjardyMetformin-768x485.png 768w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Overview-of-SynjardyMetformin-1536x970.png 1536w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Overview-of-SynjardyMetformin.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" title=\"\"><figcaption><\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p>Synjardy is an antidiabetic combination medication for T2DM. It contains <strong>empagliflozin<\/strong> (an SGLT2 inhibitor) and <strong>metformin<\/strong> (a biguanide). It aids in regulating blood glucose levels by lowering the production of glucose in the liver, thus improving insulin sensitivity, and enhancing elimination of glucose via urine.<\/p>\n\n\n\n<ul>\n<li><strong>Empagliflozin<\/strong>: Works by preventing the kidneys from reabsorbing glucose, allowing excess glucose to be expelled through urine.<\/li>\n<\/ul>\n\n\n\n<ul>\n<li><strong>Metformin<\/strong>: Works by reducing the production of glucose in the liver and improves insulin sensitivity of the body, letting it use glucose more efficaciously.\n<ul>\n<li><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"How_Synjardy_Works\"><\/span><strong>How Synjardy Works<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul>\n<li><strong>Empagliflozin<\/strong>: It falls under the class of drugs called SGLT2 inhibitors. The medication works by lowering the glucose reabsorption in the kidneys, allowing glucose elimination through urine, which aids in reducing blood sugar levels. In addition, Empagliflozin aids in weight loss and reducing blood pressure.<\/li>\n<\/ul>\n\n\n\n<ul>\n<li><strong>Metformin<\/strong>: Metformin helps by reducing the liver&#8217;s glucose output and enhancing insulin sensitivity in muscle and fat tissues. This leads to improved glucose uptake and use.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"Benefits_of_Synjardy\"><\/span><strong>Benefits of Synjardy<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul>\n<li><strong>Effective Blood Sugar Control<\/strong>: Combines two mechanisms to lower blood sugar, addressing both glucose absorption in the kidneys and production in the liver.<\/li>\n\n\n\n<li><strong>Cardiovascular Benefits<\/strong>: Empagliflozin is known to lower the risk of heart disorders in people with type 2 diabetes who have preexisting cardiovascular problems.<\/li>\n\n\n\n<li><strong>Weight Loss<\/strong>: Empagliflozin has been seen to promote weight loss owing to the excretion of glucose in the urine.<\/li>\n\n\n\n<li><strong>Lower Risk of Hypoglycemia<\/strong>: In comparison to other antidiabetics such as sulfonylureas or insulin, Synjardy has a reduced risk of causing hypoglycemia (low blood sugar).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"Dosage_Forms\"><\/span><strong>Dosage Forms<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Synjardy is available in various strengths to tailor treatment to individual patient needs. Common dosages include:<\/p>\n\n\n\n<ul>\n<li><strong>Empagliflozin\/Metformin<\/strong>: Dosages include 5 mg\/500 mg, 5 mg\/1000 mg, 12.5 mg\/500 mg, 12.5 mg\/1000 mg<\/li>\n<\/ul>\n\n\n\n<p>The dosage can be adjusted depending on the patient\u2019s needs and his or her renal function. The medication must be consumed with food to decrease the risk of gastrointestinal side effects from metformin.<\/p>\n\n\n\n<h2 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"Synjardy_Empagliflozin_Metformin_for_weight_loss\"><\/span>Synjardy Empagliflozin &amp; Metformin for weight loss<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"is-layout-flex wp-block-gallery-3 wp-block-gallery has-nested-images columns-default is-cropped\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"647\" data-id=\"3961\" src=\"https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/SynjardyMetformin-for-weight-loss-2-1024x647.png\" alt=\"Synjardy Empagliflozin &amp; Metformin for weight loss\" class=\"wp-image-3961\" srcset=\"https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/SynjardyMetformin-for-weight-loss-2-1024x647.png 1024w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/SynjardyMetformin-for-weight-loss-2-300x190.png 300w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/SynjardyMetformin-for-weight-loss-2-768x485.png 768w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/SynjardyMetformin-for-weight-loss-2-1536x970.png 1536w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/SynjardyMetformin-for-weight-loss-2.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" title=\"\"><figcaption><\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p>Both <strong>Synjardy<\/strong> <strong>empagliflozin<\/strong> and <strong>metformin<\/strong> individually have shown some potential for weight loss, however the mechanisms and results might differ between the two drugs.<\/p>\n\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"1_How_Synjardy_Affects_Weight_Loss\"><\/span><strong>1. How Synjardy Affects Weight Loss<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul>\n<li><strong>Empagliflozin (SGLT2 inhibitor)<\/strong>: This part of Synjardy works by promoting the excretion of excess glucose through urine. When glucose fails to get reabsorbed by the kidneys, it gets eliminated from the body, leading to a loss of calories. This may cause a modest weight loss, typically in the range of <strong>2-3 kg (4.4-6.6 lbs)<\/strong> over several months of treatment.<\/li>\n\n\n\n<li><strong>Metformin (Biguanide)<\/strong>: The medication aids in blood glucose regulation, however, it also has mild effects on weight. It has been found to lower appetite and slow the absorption of carbs, causing modest weight loss or weight loss. People on metformin have been seen to lose nearly <strong>1 to 2 kg (2.2-4.4 lbs)<\/strong>, however this may also vary.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"2_Weight_Loss_Benefits_of_Synjardy\"><\/span><strong>2. Weight Loss Benefits of Synjardy<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul>\n<li><strong>Dual Mechanism<\/strong>: The combination of empagliflozin and metformin in Synjardy provides a more comprehensive approach to managing blood sugar, and its impact on weight can be more pronounced than metformin alone.<\/li>\n\n\n\n<li><strong>Reduced Fat Storage<\/strong>: Empagliflozin helps reduce fat storage by eliminating excess sugar, which can otherwise contribute to fat accumulation.<\/li>\n\n\n\n<li><strong>Metabolic Improvement<\/strong>: Metformin improves the body&#8217;s sensitivity to insulin, which may prevent excessive fat storage.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"3_How_Effective_is_Synjardy_for_Weight_Loss\"><\/span><strong>3. How Effective is Synjardy for Weight Loss?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>While Synjardy may cause weight loss, it&#8217;s not recommended for this purpose. The weight loss achieved through this medication may be modest and gradual, around <strong>2-4 kg (4.4-8.8 lbs)<\/strong> over a few months, based on the person\u2019s condition. The weight reduction observed with Synjardy is often a side benefit of its blood sugar-lowering effects rather than a direct treatment for obesity.<\/p>\n\n\n\n<h2 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"Cost_of_Synjardy_Empagliflozin_Metformin\"><\/span>Cost of Synjardy Empagliflozin &amp; Metformin<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"is-layout-flex wp-block-gallery-5 wp-block-gallery has-nested-images columns-default is-cropped\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"717\" data-id=\"3962\" src=\"https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Cost-of-SynjardyMetformin-1024x717.jpg\" alt=\"Cost of Synjardy Empagliflozin &amp; Metformin\" class=\"wp-image-3962\" srcset=\"https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Cost-of-SynjardyMetformin-1024x717.jpg 1024w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Cost-of-SynjardyMetformin-300x210.jpg 300w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Cost-of-SynjardyMetformin-768x538.jpg 768w, https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Cost-of-SynjardyMetformin.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" title=\"\"><figcaption><\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p>The cost of Synjardy <strong>Empagliflozin<\/strong> and <strong>Metformin<\/strong> can vary significantly depending on several factors such as location, pharmacy, insurance coverage, dosage, and whether the medication is a brand name or generic.<\/p>\n\n\n\n<ul>\n<li>Without insurance, the price for a 30-day supply of Synjardy (ranging from 5 mg\/500 mg to 12.5 mg\/1000 mg tablets) can cost between <strong>$450 to $550<\/strong> in the U.S. Prices may be reduced to <strong>$0 to $100<\/strong> depending on your insurance plan.<\/li>\n\n\n\n<li>A 30-day supply of metformin without insurance might cost between <strong>$5 to $20<\/strong>, based on the pharmacy. Many insurance plans cover metformin, and the copay can be as low as <strong>$0 to $10<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p><strong>Synjardy<\/strong> combines empagliflozin and metformin, making it more convenient for people who need both medications, but it comes at a higher cost compared to taking metformin alone.<\/p>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1730787578140\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"What_is_the_suitable_time_to_take_Synjardy\"><\/span>What is the suitable time to take Synjardy?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"rank-math-answer \"><p>Synjardy should be taken <strong>twice daily with meals<\/strong> to reduce the risk of gastrointestinal side effects, especially those related to metformin, such as nausea or upset stomach. The medication when consumed with food helps improve absorption and reduce discomfort. It\u2019s vital to follow your doctor\u2019s dosing guidelines and have it at the same time daily if you want optimal blood sugar control. Avoid skipping doses to maintain consistent blood sugar levels.<\/p>\n<\/div>\n<\/div>\n<div id=\"faq-question-1730787597418\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Does_Synjardy_affect_the_liver\"><\/span>Does Synjardy affect the liver?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"rank-math-answer \"><p>Synjardy affects the kidneys and blood sugar levels, but it can have some impact on the liver due to its <strong>metformin<\/strong> constituent. Metformin is usually safe for the liver, but in rare cases, it can lead to <strong>lactic acidosis<\/strong>, a serious condition that might affect liver function, particularly in patients with existing liver disease. Empagliflozin, the other component, is not seen to significantly affect the liver. Regular liver function monitoring may be recommended if you have liver issues while on Synjardy.<\/p>\n<\/div>\n<\/div>\n<div id=\"faq-question-1730787618123\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Is_Metformin_good_for_diabetes\"><\/span>Is Metformin good for diabetes?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"rank-math-answer \"><p>Yes, metformin is widely regarded as a first-line treatment for <strong>type 2 diabetes<\/strong> due to its effectiveness in lowering blood sugar levels. It works by reducing glucose production in the liver and improving the body&#8217;s sensitivity to insulin. Metformin is also associated with minimal weight gain and a low risk of hypoglycemia. Additionally, it has potential cardiovascular benefits, making it a popular and generally safe choice for managing diabetes.<\/p>\n<\/div>\n<\/div>\n<div id=\"faq-question-1730787632730\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Is_Synjardy_bad_for_the_kidney\"><\/span>Is Synjardy bad for the kidney?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"rank-math-answer \"><p>Synjardy can affect the kidneys, particularly due to its <strong>empagliflozin<\/strong> component, which helps the kidneys remove excess glucose through urine. While empagliflozin can benefit people with <strong>mild to moderate kidney disease<\/strong> by protecting kidney function, it may not be suitable for those with <strong>severe kidney impairment<\/strong>. The <strong>metformin<\/strong> in Synjardy is also generally avoided in advanced kidney disease due to the risk of <strong>lactic acidosis<\/strong>. Regular kidney function monitoring is important while taking Synjardy.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<h3 class=\"has-medium-font-size\"><span class=\"ez-toc-section\" id=\"References\"><\/span>References<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/206111s004lbl.pdf\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/206111s004lbl.pdf<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/patient.boehringer-ingelheim.com\/us\/products\/synjardy\/\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/patient.boehringer-ingelheim.com\/us\/products\/synjardy\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>When it comes to managing type 2 diabetes, understanding the various treatment options available is crucial. Synjardy Empagliflozin &amp; Metformin are two commonly prescribed medications, each playing a unique role in glucose control. Metformin, often considered the first-line treatment, primarily works by reducing glucose production in the liver and improving insulin sensitivity. On the other &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/www.liferxpharmacy.com\/blog\/empagliflozin-vs-metformin\/\"> <span class=\"screen-reader-text\">Difference Between Empagliflozin &#038; Metformin<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":12,"featured_media":3967,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":""},"categories":[2,216],"tags":[616,615],"uagb_featured_image_src":{"full":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin.jpg",1280,853,false],"thumbnail":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin-150x150.jpg",150,150,true],"medium":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin-768x512.jpg",768,512,true],"large":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin-1024x682.jpg",1024,682,true],"1536x1536":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin.jpg",1280,853,false],"2048x2048":["https:\/\/www.liferxpharmacy.com\/blog\/wp-content\/uploads\/2024\/11\/Difference-Between-Empagliflozin-Metformin.jpg",1280,853,false]},"uagb_author_info":{"display_name":"Disha Goel","author_link":"https:\/\/www.liferxpharmacy.com\/blog\/author\/disha-goel\/"},"uagb_comment_info":0,"uagb_excerpt":"When it comes to managing type 2 diabetes, understanding the various treatment options available is crucial. Synjardy Empagliflozin &amp; Metformin are two commonly prescribed medications, each playing a unique role in glucose control. Metformin, often considered the first-line treatment, primarily works by reducing glucose production in the liver and improving insulin sensitivity. On the other&hellip;","_links":{"self":[{"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/posts\/3958"}],"collection":[{"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/comments?post=3958"}],"version-history":[{"count":3,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/posts\/3958\/revisions"}],"predecessor-version":[{"id":3966,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/posts\/3958\/revisions\/3966"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/media\/3967"}],"wp:attachment":[{"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/media?parent=3958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/categories?post=3958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.liferxpharmacy.com\/blog\/wp-json\/wp\/v2\/tags?post=3958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}